Floating microspheres of acyclovir pdf

Floating properties and release characteristics of hollow. Designing development and evaluation of floating gastro. The microspheres were prepared by emulsion solvent evaporation method using polymers hydroxyl propyl methyl cellulose, ethyl cellulose, eudragit s100 and eudragit rl. Pdf sustained release floating microspheres of acyclovir. Acyclovir loaded floating microspheres were prepared by double emulsion solvent evaporation method. Pornsuwannapha developed hollow microspheres of acv that were capable of floating on gastric.

The floating microspheres showed particle size, buoyancy, drug entrapment efficiency and yield in the ranges of 251 387 m, 74. Rjpt development and characterization of cellulose and. Pdf multiunit floating drug delivery system of acyclovir. Formulation and invitro characterization of acyclovir floating. Floating behavior of floating microsphere12,37 100 mg of the floating microsphere were placed in 0. The prepared floating microspheres were evaluated for flow properties by. Merck manual online drug library and uchida t, yoshida k. Pdf preparation and in vitro evaluation of floating. The present study involves preparation and evaluation of floating microspheres of acyclovir as model drug for prolongation of gastric residence time. Pdf the aim of the present work was to prepare floating microspheres of acyclovir to prolong residence time in stomach and to sustain the release of.

Keywords acyclovir, eudragit s100, floating microspheres, hollow. In vitro evaluation of acyclovirchitosan floating systems mdpi. Hollow microspheres of acyclovir hollow microspheres of acyclovir were prepared by the methoddescribedaboveandusing1gofeudragits100anddifferent amounts 100, 200, 400, 600 and 800 mg of acyclovir. Pharmacokinetic study in rats showed nearly two times higher auc value of acyclovir for the microspheres with piperine 15614. Formulation and evaluation of sustained release gastro. The shape and surface morphology of the microspheres were characterised by optical and scanning electron microscopy. Microspheres, solvent evaporation diffusion, controlled. Choudhary, department of pharmaceutics, alameen college of pharmacy, near lalbagh main gate, hosur road, bangalore 560027, india department of pharmaceutics, alameen college of pharmacy, near. The highest percent drug entrapment was obtained at the ratio of 600 mg acyclovir. In thismethod, acyclovirpowderwasaddedtodichloromethanebefore adding to the polymer solution of ethanol and isopropanol. The layer of buoyant microspheres was pipetted and separated by filtration at 1, 2, 4 and 6 hours. Microspheres are able to incorporate a wide range of different drugs, they are biocompatible and can be prepared from biodegradable particles. Microspheres formulated from biodegradable particles such as polyd, llactide and polyd, llactidecoglycolide with encapsulated antiviral drug acyclovir have been proposed for intraocular. Floating properties and release characteristics of.

The objective was to develop floating microspheres of vch to localise the drug at upper part of git, for improved absorption. Development and evaluation of floating microspheres of. Pdf the aim of the present work was to prepare floating microspheres of acyclovir to prolong residence time in stomach and to sustain the. The resulting slurry was introduced into a 250 ml beaker containing 200 ml 0. Formulation and in vitro evaluation of floating microspheres of. Floating microspheres have been gaining attention due. The purpose of the present study was preparation and in vitro evaluation of the floating microspheres of two drugs gabapentin and acyclovir as gastroretentive drug delivery systems. Floating microspheres are multiple unit gastroretentive drug delivery systems. Pdf preparation and in vitro evaluation of floating microspheres. Introduction acyclovir 92hydroxyethoxymethyl guanine. Microspheres were having sufficient entrapment efficiency and floating ability and were directly proportional to the polymer concentration. Briefly, the drug and polymer blends were mixed in the solvent ethanoldichloromethane, 1. Floating microspheres are, in a strict sense, spherical empty particles without a core. Floating microspheres are gastroretentive drug delivery systems based on a noneffervescent approach.

Multiunit floating drug delivery system of acyclovir. The floating microspheres of acv are potential drug delivery system for the enhancement of oral bioavailability of acv. Sustained release floating microspheres of acyclovir. The collected microspheres were dried in desiccators over night. Preparation of floating microspheres floating microspheres were prepared by emulsion solvent diffusion method 7. Valacyclovir hydrochloride vch is lvalyl ester prodrug of acyclovir. The 3 2 full factorial design was applied to optimize the formulation.

Acyclovir loaded floating microspheres were prepared by emulsion solvent diffusion method with combination of polymers. Hollow microspheres, microballoons or floating microparticles are terms used synonymously for floating microspheres. Preparation and in vitro evaluation of floating microspheres of gabapentin and acyclovir. The hollow microspheres of acyclovir were prepared by spraydrying method using ethyl cellulose as a drugcontrolled release polymer.